1 Woodward, R. B. and Doering, W. E. (1944) The Total Synthesis of Quinine, J. Am. Chem. Soc. 66, 849. For the full account, see: R. B. and Doering, W. E. (1945) The Total Synthesis of Quinine, J. Am. Chem. Soc. 67, 860.

2 Woodward, R. B., Cava, M. P., Ollis, W. D., Hunger, A.; Daeniker, H. U. and Schenker, K. (1963) The Total Synthesis of Strychnine, Tetrahedron 19, 247.

3 See (a) Woodward, R. B. (1973) The Total Synthesis of Vitamin B12 Pure Appl. Chem. 33, 145, (b) Eschenmoser, A. and Wintner, C. (1977) Natural Product Synthesis and Vitamin B12 Science 196, 1410, and the many previous references cited in these two publications. See also, (c) Eschenmoser, A. (1988) Vitamin B12: Experiments Concerning the Origin of Its Molecular Structure Angew. Chem., Internat. Edn. Engl. 27, 5.

4 Armstrong, R. W., Beau, J.-M., Cheon, S. H., Christ, W. J., Fujioka, H., Ham, W.-H., Hawkins, L. D., Jin, H., Kang, S. H., Kishi, Y., Martinelli, M. J., McWhorter, Jr., W. W., Mizuno, M., Nakata, M., Stutz, A. E., Talamas, F. X., Taniguchi, M., Tino, J. A., Ueda, K., Uenishi, J.-i., White, J. B. and Yonaga, M. (1989) J. Am. Chem. Soc. 111, 7530.

5 Heathcock, C. H. (1992) The Enchanting Alkaloids of Yuzuriha, Angew. Chem. 104, 675; Angew. Chem. Int. Ed. Engl. 31, 665.

6 Stein, J. (1979) The Random House Dictionary of the English Language, Random House, New York.

7 Heathcock, C. H., Finkelstein, B. L., Aoki, T. and Poulter, C. D. (1985) Stereostructure of the Archaebacterial C40 Diol, Science, Washington, D.C. 229, 862.

8 Nerenberg, J. B., Hung, D. T., Somers, P. K. and Schreiber, S. L. (1993) Total Synthesis of the Immunosuppressive Agent (-)-Discodermolide J. Am. Chem. Soc. 115, 12621.

9 Wöhler, F. (1828) Über künstliche Bildung des Harnstoffs Ann. Physik 12, 253.

10 Panelist Eschenmoser refers to synthetic work on the Daphniphyllum alkaloids. For a leading reference, see [5].