Isaac Mitchell, born about 1765, married Sarah (Sally) Shackelford, daughter of Richard and Mary Ann Roberts-Shackelford, and known to have had the following children: Frances, Mary, Richard S., Daniel and Isaac, Jr. Last known address--Madison Co, Alabama.508

Since Richard Shackelford, Sr., and Richard, Jr., were both living in Laurens County, S. C., in 1802, it is reasonable to assume that Isaac Mitchell was living in the or near the same place. It also appears reasonable to assume that Isaac Mitchell left there soon after 1802, or that his wife died soon after that date, or there would have been other children born and recorded in the same Bible.
Records of Madison County, Alabama, show that he, Isaac Mitchell, went to that County. But there is nothing to show that he died there. Other descendants claim that the Mitchells moved to Texas.509

There is an Isaac Mitchell buried in the Rice Cemetery on the west side of New Market Pike between Huntsville and New Market, and about 1.5 miles south of New Market.510

"Isaac W. Mitchel - Born 8 Oct 1820 - Died 11 Sept 1871"

The 1850 census shows:

Mitchell, Isaac 30 Ala Farmer $1000
Mary 52 SC
Evaline 22 Ala
Ann 19 Ala
Mary 23 Ala
Andrew 13 Ala
James 11 Ala

From his birth date, this is probably a grandson of the Isaac Mitchell who married Sarah Shackelford.

When Richard Shackelford wrote his will the first legatee named was his son-in-law Isaac Mitchell, thus leading us to believe that his daughter -- wife of Isaac Mitchell, was desceased. He named the daughters and their husbands that are known to have been living at that time.

So from the will we do not know names of his daughters that married Isaac Mitchell and Abner Pyles, but he had a son Richard, Jr., born June 26, 1787, married Frances Arnold, later moved to Texas and died in Smith County, Texas, in 1868.